Nuevo paper en Alzheimer’s & Dementia: Journal de Alzheimer´s Association

“Benchmarking speech biomarkers of Alzheimer’s against cognitive and neural measures.”
Caro, I., Pérez, G., Valdés Bize, J., Ponferrada, J., Ferrante, F. J., Sosa Welford, A., Gauder, L., Olavarría, L., Henríquez, F., Ramos, T., Besnier, C., Ferrer, L., Gorno-Tempini, M. L., Slachevsky, A., Ibañez, A. & García, A. M

Abstract


INTRODUCTION
Digital speech biomarkers (DSBs) support the detection and monitoring of Alzheimer’s disease (AD) in Latinos. However, they have not been benchmarked against standard cognitive and neuroimaging measures, missing a critical validation milestone.

METHODS
Thirty-three AD patients and 33 healthy controls completed verbal fluency tasks, episodic memory and executive tests, and magnetic resonance imaging (MRI) (volume) and functional MRI (fMRI) (connectivity) scans. Between-group machine learning classification was compared among fluency-derived DSBs, episodic and executive test scores, MRI, and fMRI measures.

RESULTS
The fluency classifier’s performance (area under the curve [AUC] = 0.84) was comparable (p > 0.14) to the episodic (AUC = 0.90), executive (AUC = 0.79), and structural (AUC = 0.90) classifiers and superior to the functional classifier (AUC = 0.65, p = 0.002). Top discriminating features were word length and frequency, both associated with right (pre)frontal volume upon adjusting for sociodemographic factors.

DISCUSSION
DSBs appear non-inferior to standard cognitive and imaging measures, supporting scalable AD assessments in Latinos.

Highlights

  • We examined digital speech biomarkers (DSBs) for detecting AD in Latinos.
  • DSBs were benchmarked against cognitive and neuroimaging features.
  • DSB-based classifiers matched or outperformed cognitive and brain classifiers.
  • Top DSBs included word length, phonological neighborhood, and frequency.
  • Word length and frequency correlated with right (pre)frontal brain volume.

Link al articulo: https://doi.org/10.1002/alz.71365